Fri Dec 23 2022

26 articles - From Friday Dec 16 2022 to Friday Dec 23 2022

parm_toc.knit

Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Kidney Dis

Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline.

A greater percentage of children with CKD were identified as hypertensive based on both clinic and ambulatory blood pressure when using the 2017 vs the 2004 guidelines, and the 2017 guidelines better discriminated those with higher levels of proteinuria. The substantial differences in the classification of hypertension when using the 2004 vs 2017 guidelines should inform clinical care.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Association of an Acute Kidney Injury Follow-up Clinic With Patient Outcomes and Care Processes: A Cohort Study.

Specialized post-discharge follow-up for AKI survivors was not associated with a lower risk of major adverse kidney events but was associated with a lower risk of death and increased prescriptions for some cardioprotective medications.

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Sex and Gender in Randomized Controlled Trials of Adults Receiving Maintenance Dialysis: A Meta-epidemiologic Study.

RCTs in dialysis are representative of the general dialysis population with regard to sex and gender but uncommonly report both, and often do not include either in their reporting or analysis.

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Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial.

In patients with rapidly progressing ADPKD, treatment with venglustat at either 8 mg or 15 mg showed no change in the rate of change in TKV and a faster rate of eGFR decline in the STAGED-PKD trial despite a dose-dependent decrease in plasma glucosylceramide (GL-1) levels.

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Clin J Am Soc Nephrol

Circulating Metabolites Associated with Albuminuria in a Hispanic/Latino Population.

Our study identified associations of albuminuria with metabolites involved in glucose dysregulation, and essential fatty acids and precursors of arachidonic acid in Hispanics/Latinos.

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Incidence and Risk Factors for Pruritus in Patients with Nondialysis CKD.

A substantial proportion of patients with nondialysis CKD develop moderate-to-severe pruritus. While lower eGFR is associated with the risk of pruritus, other comorbidities, particularly depressive symptoms, are potential risk factors.

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Maintenance of Remission and Risk of Relapse in Myeloperoxidase Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Kidney Involvement.

Persistence or subsequent reappearance of MPO-ANCA is associated with an increased risk of relapse. Serial MPO-ANCA determinations can inform the development of remission-maintenance strategies in patients with MPO-ANCA associated vasculitis with glomerulonephritis.

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J Am Soc Nephrol

Tet2- and Tet3-Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

-mediated active cytosine hydroxymethylation in NPCs play a key role in kidney development and nephron endowment.

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HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.

HNF1B activates an evolutionarily conserved program of target genes that disease-causing mutations selectively disrupt. These findings provide insights into the renal transcriptional network that controls nephrogenesis.

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Nephrol Dial Transplant

Fasting influences aquaporin expression, water transport and adipocyte metabolism in the peritoneal membrane.

Fasting induces a coordinated regulation of lipolytic and lipogenic factors and aqua(glycero)porins in the peritoneum, driving structural and functional changes. These data yield novel information on the specific roles of aquaporins in the peritoneal membrane and indicate that fasting improves fluid removal in a mouse model of PD.

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Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTR: results from two prospective cohort studies.

Plasma endotrophin is strongly associated with graft failure and mortality among KTR. These findings suggest a key role of abnormal extracellular matrix turnover and fibrosis in graft and patient prognosis among KTR, and highlight the need for (interventional) studies targeting the pro-fibrotic state of KTR. The intra-individual stability after transplantation indicates potential use of endotrophin as a biomarker and outcome measure of fibrosis.

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Sleep duration and cognitive function among older adults with chronic kidney disease - results from the National Health and Nutrition Examination Survey (2011-2014).

Longer sleep duration is associated with worse cognitive function only among persons with CKD and global cognition, delayed recall, and verbal fluency are particularly affected. Studies should identify interventions to improve sleep patterns and quality in this population.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Kidney Dis

Much Ado About Something: The Clinical Pattern of Tolvaptan-Associated Liver Injury in Participants With ADPKD.

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Renal Thrombotic Microangiopathy: A Review.

This article will review the clinical presentation and pathologic hallmarks of TMA involving the kidney, and the disease-specific mechanisms that contribute to the endothelial injury that characterizes TMA lesions. Diagnostic approach, and both empiric and disease-specific treatment strategies will be discussed, along with the potential role for emerging targeted disease-specific therapies.

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Urine-to-Plasma Urea Ratio: Disentangling Tubular Concentrating Ability From GFR.

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Kidney Int

Renal AA Amyloidosis: presentation, diagnosis, and current therapeutic options: a review.

This strategy has also shown efficacy in cases where an underlying etiology cannot be readily identified and has significantly improved the prognosis of this entity. In addition, there has been increased interest at developing effective therapies able to clear amyloid deposits from tissues albeit with mitigated results so far.

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Nephrol Dial Transplant

Reducing polymicrobial and enteric peritonitis: a gut response.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Kidney Int

Cord blood effectively resists mineralisation through mechanisms that stabilise calciprotein particles.

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Nat Rev Nephrol

Efficacy of empagliflozin for syndrome of inappropriate antidiuresis.

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Glucocorticoids block T cell recruitment.

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Insights into glomerular function and disease pathogenesis.

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Insights into the impact of pregnancy on kidney disease.

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Iron deficiency of kidney macrophages in CKD.

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Paths to organ damage and risk factors in AKI.

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The evolving landscape of immune-mediated glomerular diseases.

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Nephrol Dial Transplant

The foundation and the four pillars of treatment for cardiorenal protection in people with chronic kidney disease and type 2 diabetes.

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Letters&Replies

Letters to the editors and authors’ replies